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Article History

Received: 24 November 2020

Accepted: 19 February 2021

First Online: 9 March 2021

Declarations

:

: Bamias G. has served as advisor/lecturer for Janssen, Pfizer, Takeda, Abbvie, MSD, Mylan, Genesis Pharma, Adacyte Therapeutics, Amgen, Ferring and Cooper, received funding (Grants/Honoraria) from Pfizer, Takeda, Abbvie and Aenorasis and participated in research/Clinical Trials by Abbvie and Takeda. Karmiris K. has served as advisor/lecturer for Abbvie, Aenorasis, Janssen, MSD, Pfizer, Takeda, Amgen, Ferring, Galenica and Genesis Pharma. Michopoulos S. has served as advisor/Lecturer for Pfizer, Takeda, Abbvie, Ferring, MSD and Janssen. Viazis N. has served as Advisor/lecturer for Janssen, Pfizer, Aenorasis, Takeda, Abbvie, MSD, Mylan, Amgen, Genesis Pharma and Cooper. Tsironi E. has served as lecturer for Ferring and Takeda. Tzouvala M. has served as advisor/lecturer for Janssen, Pfizer, Takeda, Abbvie, MSD, Mylan, Genesis Pharma and Amgen and participated in research/Clinical Trials by AbbVie, Gilead and Takeda. Zampeli E. has served as advisor/lecturer for Pfizer, Takeda, Abbvie, Amgen, Genesis Pharma, Aenorasis and Janssen. ΚΤ has served as Lecturer for Takeda and Amgen. Papatheodoridis G. has served as advisor/lecturer for Abbvie, Dicerna, Elpen, Gilead, GlaxoSmithKline, Ipsen, Janssen, Merck Sharp & Dohme; Roche, Spring Bank and Takeda, received research grants from Abbvie, Gilead and Takeda and participated in clinical trials by Abbvie, Astellas, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead, Janssen, Merck Sharp & Dohme, Noorik, Novartis, NovoNordisk, Regulus, Roche and Takeda. Mantzaris G. has served as advisor/lecturer for AbbVie, Celgene, Celtrion, Ferrirng, Genesis, Hospira, Janssen, Millennium Pharmaceuticals, MSD, Mylan, Pharmacosmos, Pfizer, Takeda, VIANEX, Angelini, Falk Pharma, Galenica, Omega Pharma, consulter for MSD and Takeda and received research support from AbbVie, Galenica, Genesis, Menarini Group, MSD and Pharmathen.

: All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Hospitals’ institutional review boards (IRBs), and all patients were informed for the study and signed a consent form for participation.

: Informed consent was obtained from all individual participants included in the study.