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Article History

Received: 24 May 2016

Accepted: 2 August 2016

First Online: 5 September 2016

Compliance with ethical standards

:

: The study was designed and funded by Nippon Kayaku Co., Ltd. NK105 was provided by Nippon Kayaku. Nippon Kayaku collected and analyzed the data and contributed to the interpretation of the results.

: Yasuhiro Matsumura received consigned research funding from Nippon Kayaku. Rika Goda, Takayuki Hirai, and Yoshihiro Nambu are employees of Nippon Kayaku. The other authors have no conflict of interest.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee as well as with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was conducted in compliance with the International Conference on Harmonization of Good Clinical Practice Guidelines. Before the initiation of the study, the protocol had been reviewed and approved by the institutional review board of each institution.

: Informed consent was obtained from all individual participants included in the study.