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Article History

Received: 30 January 2017

Accepted: 16 March 2017

First Online: 28 March 2017

Compliance with ethical standards

:

: EC has served on advisory boards for Castle Biosciences, Taiho, EMD-Serono, Amgen, Lilly, Advaxis, Bayer and Merrimack and has institutional research funding from Merrimack, Advaxis, Bristol Myers Squibb, Genentech, Array BioPharma, Leap Therapeutics, Aduro Biotech, and Karyopharm Therapeutics. LWG has served as a consultant for Celgene and has institutional research funding from Astellas Pharma, Pfizer, Onyx, SunPharma, Lilly, and Bristol-Myers Squibb. DBC has served as a consultant for Merrimack and has institutional research funding from Synta, Incyte, Celgene, Hoffman-LaRoxhe, EMD-Serono, and Oncolytics Biotech. JB has served as a consultant for Celgene, Genentech, Aduro, Boston Biomedical, Janssen, Cornerstone, Symphogen, and Bayer and has institutional research funding from Genentech, Abbvie, Taiho, Bayer, FivePrime, Phoenix, Incyte, and Vertex. All other authors have no conflicts to disclose.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained for all individual participants included in the study.