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Article History

Received: 26 May 2018

Accepted: 28 June 2018

First Online: 3 July 2018

Compliance with ethical standards

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: Haruyasu Murakami has received honoraria from Boehringer Ingelheim, Pfizer, Chugai Pharma, Taiho Pharmaceutical, AstraZeneca, Eli Lilly, Ono Pharmaceutical, Bristol-Myers Squibb, Novartis, Merck Sharp & Dohme, and a grant from AstraZeneca. Haruki Kobayashi has received honoraria from MSD K.K. and Taiho Pharmaceutical. Kazuhisa Nakashima has received honoraria from Chugai Pharma, Boeringer Ingelheim and Novartis Pharma. Shota Omori has received honoraria from MSD K.K. Kazushige Wakuda has received honoraria from AstraZeneca, Chugai Pharmaceutical, Boeringer Ingelheim, Eli Lilly, Taiho Pharmaceutical, Ono Pharmaceutical, and a grant from AstraZeneca. Akira Ono has received honoraria from Chugai Pharmaceutical, Taiho Pharmaceutical, Ono Pharmaceutical, and grants from Chugai Pharma and Taiho Pharmaceutical. Hirotsugu Kenmotsu has received honoraria from AstraZeneca, Chugai Pharmaceutical, Bristol-Myers, Boeringer Ingelheim, Eli Lilly, Kyowa Hakko Kirin, MSD K.K., Novartis Pharma, and grants from AstraZeneca, Chugai Pharmaceutical and Boehringer Ingelheim. Tateaki Naito has received honoraria from Ono Pharmaceutical. Masahiro Endo has received honoraria from AstraZeneca and Ono Pharmaceutical. Toshiaki Takahashi has received honoraria from Eli Lilly, AstraZeneca, Chugai Pharma, MSD, Ono Pharmaceutical, Novartis Pharma, Roche Diagnostics, and grants from Eli Lilly, AstraZeneca, Chugai Pharma, MSD, and Ono Pharmaceutical. For the remaining authors no conflicts of interest are declared.

: All procedures performed on the patient were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from the patient.