Abuhadra, Nour
Sun, Ryan
Bassett, Roland L. Jr
Huo, Lei
Chang, Jeffrey T.
Teshome, Mediget
Clayborn, Alyson R.
White, Jason B.
Ravenberg, Elizabeth E.
Adrada, Beatriz E.
Candelaria, Rosalind P.
Yang, Wei
Ding, Qingqing
Symmans, W. Fraser
Arun, Banu
Damodaran, Senthil
Koenig, Kimberly B.
Layman, Rachel M.
Lim, Bora
Litton, Jennifer K.
Thompson, Alastair
Ueno, Naoto T.
Piwnica-Worms, Helen
Hortobagyi, Gabriel N.
Valero, Vicente
Tripathy, Debu
Rauch, Gaiane M.
Moulder, Stacy
Yam, Clinton
Funding for this research was provided by:
The Susan Papizan Dolan Fellowship in Breast Oncology
National Institutes of Health (CA016672, U54CA209978)
Moon Shots Program of The University of Texas MD Anderson Cancer Center
Cancer Prevention and Research Institute of Texas (RP170668)
Still Water Foundation
Novartis Pharmaceuticals Corporation
Pfizer
The Winterhof Fund
Conquer Cancer Foundation (12266)
The Allison and Brian Grove Endowed Fellowship for Breast Medical Oncology
Article History
Received: 21 January 2023
Accepted: 27 March 2023
First Online: 12 April 2023
Declarations
:
: E.E.R. is currently employed at Eli Lilly (previously employed by MD Anderson at the time the study was conducted). W.F.S. is a co-inventor/patent of US Patent No. 11,459,617 “Targeted measure of transcriptional activity related to hormone receptors” issued on 10/4/2022 (applicant proprietor: University of Texas MD Anderson Cancer Center. Licensed to Delphi Diagnostics, Inc. and has co-founder equity from Delphi Diagnostics, Inc. R.L. has received research funding (to the institution) from Novartis and serves on the advisory board for Novartis. J.K.L. has received grant or research support from Novartis, Medivation/Pfizer, Genentech, GSK, EMD-Serono, Astra-Zeneca, Medimmune, Zenith, Jounce; participated in Speaker’s Bureau for MedLearning, Physician’s Education Resource, Prime Oncology, Medscape, Clinical Care Options; received honoraria from UpToDate; served on advisory committees or review panels for Astra-Zeneca, Ayala, Pfizer (all uncompensated), NCCN, ASCO, NIH, PDQ, SITC Breast Committee, SWOG Breast Committee. A.T. is related by marriage to an employee of Eli Lilly. D.T. has received research support (to the institution) from Novartis, Pfizer, Polyphor and has served as a consultant to AstraZeneca, Glaxosmithkline, Gilead, Oncopep, Pfizer, Novartis, AMBRX, Personalis, Sermonix, Stemline-Menarini, Puma Biotechnology. S.L.M. is currently employed by Eli Lilly (previously employed by MD Anderson at the time the study was conducted). All other authors declare that they have no relevant conflicts of interest. C.Y. has received research funding (to the institution) from Genentech, Gilead, BostonGene, Sanofi, Amgen, Pfizer, Astellas, Novartis and has served on advisory boards for Gilead. All other authors declare no relevant conflicts of interest.
: Funding and drug support were provided (in part) by Novartis AG; Pfizer Inc. This work was funded by generous philanthropic contributions to the Moon Shots Program of The University of Texas MD Anderson Cancer Center, the Still Water Foundation (to D. Tripathy), and the Winterhof fund (to S.L. Moulder). Pre-sequencing processing work was completed by the Cancer Genomics Laboratory Moon Shots Platform and the Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy at The University of Texas MD Anderson Cancer Center. Sequencing and data generation was supported by the CA016672 grant from The University of Texas MD Anderson Cancer Center. Dr. Yam was additionally supported by a Conquer Cancer Career Development Award supported by Fleur Fairman, the 2018 Gianni Bonadonna Breast Cancer Research Fellowship (Conquer Cancer Foundation), the Allison and Brian Grove Endowed Fellowship for Breast Medical Oncology, and the Susan Papizan Dolan Fellowship in Breast Oncology. Dr. Chang was supported by the Cancer Prevention Research Institute of Texas (RP170668, RP160710) and the National Institutes of Health’s National Cancer Institute (U54CA209978). Any opinions, findings, and conclusions expressed in this material are those of the author(s) and do not necessarily reflect those of the sponsors.