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Authors
Posthumus, Anna M. https://orcid.org/0009-0001-6520-6830
Knobbe, Tim J. https://orcid.org/0000-0003-3246-3192
Kremer, Daan https://orcid.org/0000-0003-0011-115X
Gomes-Neto, Antonio W. https://orcid.org/0000-0002-4398-4877
Dielwart, Isabelle J. C. https://orcid.org/0009-0003-8270-1926
Jonker, Jip https://orcid.org/0009-0006-9548-4985
Doorenbos, Caecilia S. E. https://orcid.org/0000-0001-8036-520X
Eisenga, Michele F. https://orcid.org/0000-0002-2484-6233
van Londen, Marco https://orcid.org/0000-0001-7145-3240
Douwes, Rianne M. https://orcid.org/0000-0002-2517-5769
Nieuwenhuis, Lianne M. https://orcid.org/0000-0003-1159-787X
Annema, Coby https://orcid.org/0000-0001-8663-2145
de Boer, Marieke T. https://orcid.org/0009-0008-0634-4740
de Borst, Martin H. https://orcid.org/0000-0002-4127-8733
Damman, Kevin https://orcid.org/0000-0003-0190-2228
Pol, Robert A. https://orcid.org/0000-0002-2236-5233
Gan, C. Tji https://orcid.org/0000-0002-1310-4189
Verschuuren, Erik A. M. https://orcid.org/0000-0002-6807-6744
Blokzijl, Hans https://orcid.org/0000-0003-4240-7506
de Meijer, Vincent E. https://orcid.org/0000-0002-7900-5917
Bakker, Stephan J. L. https://orcid.org/0000-0003-3356-6791
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Annema, Coby
Berger, Stefan P.
Blokzijl, Hans
Bodewes, Frank A. J. A.
de Boer, Marieke T.
Damman, Kevin
de Borst, Martin H.
Diepstra, Arjan
Dijkstra, Gerard
Douwes, Rianne M.
Doorenbos, Caecilia S. E.
Eisenga, Michele F.
Erasmus, Michiel E.
Gan, C. Tji
Gomes-Neto, Antonio W.
Hak, Eelko
Hepkema, Bouke G.
van den Heuvel, Marius C.
Jonker, Jip
Klont, Frank
Knobbe, Tim J.
Kremer, Daan
van Leer-Buter, Coretta
Leuvenink, Henri G. D.
van Londen, Marco
Lexmond, Willem S.
de Meijer, Vincent E.
Niesters, Hubert G. M.
Nieuwenhuis-Moeke, Gertrude J.
van Pelt, L. Joost
Pol, Robert A.
Posthumus, Anna M.
Ranchor, Adelita V.
Sanders, Jan Stephan F.
Siebelink, Marion J.
Slart, Riemer J. H. J. A.
Swarte, J. Cas
Touw, Daan J.
Velde-Keyzer, Charlotte A.
Verschuuren, Erik A. M.
Vos, Michel J.
Weersma, Rinse K.
Bakker, Stephan J. L.
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Funding
Funding for this research was provided by:
Astellas Pharma, Netherlands (TransplantLines Biobank, Cohort study)
Chiesi Pharmaceuticals BV (PA-SP/PRJ-2020-9136)
DSM, Animal Nutrition and Health (project code: 14939)
Ministerie van Economische Zaken en Klimaat (project code: PPP-2019-032, PPP-2022-015)
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Article History
Received: 23 May 2025
Accepted: 27 May 2025
First Online: 2 July 2025
Declarations
:
: MB reports a grant from CSL Vifor, outside the submitted work. Additionally, MB reports consulting fees paid to his institution by Astellas, Astra Zeneca, Bayer, Boehringer Ingelheim, CSL Vifor, Kyowa Kirin Pharma, Lilly and Sanofi Genzyme. KD reports consulting fees from Abbot, Astra Zeneca, Boehringer Ingelheim, Novartis, Echosense, FIRE1 and Reprieve paid to his institution. TG reports participation on a data safety monitoring board or advisory board from Chiesi pharmaceuticals, payments paid to his institution. VM reports a VENI research grant by the Dutch Research Council (NWO; grant #09150161810030), a Research grant from the Dutch Ministry of Economic Affairs (Health ~ Holland Public Private Partnership grant #PPP31 2019–024), and a Research grant from the Dutch Society for Gastroenterology (NVGE #01–2021), all outside the submitted work. VM further reports speakers fees paid to his institution by Astellas, Chiesi, and XVIVO. All above reported conflict of interest are not directly involved in this manuscript. The remaining authors do not have conflicts of interests to report.
: The study protocol has been approved by the local Institutional Review Board (METc 2014/077), adheres to the UMCG Biobank Regulation, and complies with the WMA Declaration of Helsinki and the Declaration of Istanbul [].
: Written informed consent was obtained from all participants prior to inclusion for all recipients and living donors. For deceased donors, informed consent was obtained from their relatives, following the applicable regulations and agreements of the Dutch Transplant Foundation (NTS) regarding participation and use in scientific research.
: Coby Annema, Stefan P Berger, Hans Blokzijl, Frank AJA Bodewes, Marieke T de Boer, Kevin Damman, Martin H de Borst, Arjan Diepstra, Gerard Dijkstra, Rianne M Douwes, Caecilia SE Doorenbos, Michele F Eisenga, Michiel E Erasmus, C Tji Gan, Antonio W Gomes-Neto, Eelko Hak, Bouke G Hepkema, Marius C van den Heuvel, Jip Jonker, Frank Klont, Tim J Knobbe, Daan Kremer, Coretta van Leer-Buter, Henri GD Leuvenink, Marco van Londen, Willem S Lexmond, Vincent E de Meijer, Hubert GM Niesters, Gertrude J Nieuwenhuis-Moeke, L Joost van Pelt, Robert A Pol, Anna M Posthumus, Adelita V Ranchor, Jan Stephan F Sanders, Marion J Siebelink, Riemer JHJA Slart, J Cas Swarte, Daan J Touw, Charlotte A te Velde-Keyzer, Erik AM Verschuuren, Michel J Vos, Rinse K Weersma, Stephan JL Bakker.
