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Modulatory effects of Withania somnifera supplementation on p38 MAPK/NF-κB/COX-2 and TRPC1/CHOP signaling pathways in methotrexate-induced parotid and submandibular salivary gland toxicity in rats

Crossref DOI link: https://doi.org/10.1007/s10735-025-10705-y

Published Online: 2026-01-23

Published Print: 2026-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Moubarak, Hanaa Salem

Mohamed, Abdelaleem Abdelnour

Ali, Sayed Fouad El-sheikh

Abdallah, Ahlam M.

Abdelzaher, Walaa Yehia
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Text and Data Mining valid from 2026-01-23

Version of Record valid from 2026-01-23
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Article History

Received: 18 November 2025

Accepted: 18 December 2025

First Online: 23 January 2026

Declarations

:

: The authors declare no competing interests.

: The protocol of the present study was approved by the Ethical Committee, Faculty of Dentistry, Minia University (Ethics approval no. 874/2023, Committee no. 102). All experiments were performed in accordance with the National Research Council guidelines for the use and care of laboratory animals and complied with the ARRIVE guidelines.

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