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Integrative analysis of single-cell and bulk RNA sequencing data using machine learning identifies PTGDS as a key subsynovial fibroblast gene in osteoarthritis

Crossref DOI link: https://doi.org/10.1007/s10735-026-10789-0

Published Online: 2026-04-09

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Weiwei

Niu, Chicheng

Zhao, Canbin

Xu, Qingyuan

Guo, Liang

Liu, Jinfu

Zeng, Ping
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82305272)

National Natural Science Foundation of China (82160913)

Natural Science Foundation of Guangxi Zhuang Autonomous Region (2025GXNSFAA069163)
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Text and Data Mining valid from 2026-04-01

Version of Record valid from 2026-04-01
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Article History

Received: 18 October 2025

Accepted: 27 March 2026

First Online: 9 April 2026

Declarations

:

: The authors declare no competing interests.

: The animal study was reviewed and approved by the Animal Welfare and Ethics Committee of Guangxi University of Chinese Medicine (Approval No. DW20210907-169). University’s Animal Experiment Center, Certificate of Conformity: SYXK (GUI) 2019-0001. Clinical trial number: not applicable.

: Not applicable.

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