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Article History

Received: 29 July 2025

Accepted: 3 October 2025

First Online: 20 October 2025

Change Date: 16 November 2025

Change Type: Update

Change Details: In the original online version of this article, the funding statement has been updated from "This study was supported by an unrestricted grant from the Merck Sharp & Dohme (MSD)" to "This study was supported by an unrestricted grant from Merck KGaA, Darmstadt, Germany".

Declarations

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: The local Ethics Committee of the hospitals involved approved the study, and all participants gave their written informed consent for blood sampling and genetic investigations.

: LC and MS report payment of honoraria for lectures from Merck. NLV reports honoraria and support for attending meetings from Merck, Merck Sharp and Dohme, and Ferring. CB reports grants from Gedeon Richter, Ferring Pharmaceuticals, and Merck A/S, and payment of honoraria from Gedeon Richter, Ferring Pharmaceuticals, Merck A/S, Abbott, Organon, and Merck A/S. NPP reports grants from Merck Serono, Organon, Ferring Pharmaceuticals, Besins Healthcare, and Theramex; consulting fees from Merck Serono, Organon, Besins Healthcare, and IBSA; and payment of honoraria from Merck Serono, Organon, Theramex, Roche Diagnostics, IBSA, Besins Healthcare, and Ferring. All other authors declare no competing interests.