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Molecular mechanism of aspartame recognition by the human sweet taste receptor T1R2–T1R3 revealed by homology modeling and molecular dynamics simulations

Crossref DOI link: https://doi.org/10.1007/s10822-026-00780-y

Published Online: 2026-03-10

Published Print: 2026-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Tong, Mingqiong

Duan, Shengqi

Wang, Lanlan

Yin, Yuewen

Chen, Lin

Zhao, Yanyan

Liu, Bo

Gu, Xiangling

Cao, Zanxia
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82572905)

National Natural Science Foundation of China (22375028)

National Natural Science Foundation of China (32571444)

Natural Science Foundation of Shandong Province (ZR2023QB247)
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Text and Data Mining valid from 2026-03-10

Version of Record valid from 2026-03-10
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Article History

Received: 1 December 2025

Accepted: 19 February 2026

First Online: 10 March 2026

Declarations

:

: The authors declare no conflict of interest, financial or otherwise.

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