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Article History

Received: 4 January 2019

Accepted: 27 May 2019

First Online: 31 May 2019

Compliance with ethical standards

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: In accordance with ethical obligations as researchers, Drs. Thorndike and Ritterband report having a financial and/or business interest in BeHealth Solutions and Pear Therapeutics, two companies that develop and disseminate digital therapeutics, including by licensing the therapeutic developed, based in part, on early versions of the software utilized in research reported in the enclosed paper. These companies had no role in preparing this manuscript. Some of the research in this paper was conducted while Dr. Thorndike was a faculty member at the University of Virginia. At that time for Dr. Thorndike, and ongoing for Dr. Ritterband, the terms of these arrangements have been reviewed and approved by the University of Virginia in accordance with its policies. Dr. Ritterband and Dr. Palermo are also consultants to Mahana Therapeutics, a separate digital therapeutic company not affiliated with this research. Kelly M. Shaffer, Fabian Camacho, Holly R. Lord, Philip I. Chow, Emily Law, and Karen S. Ingersoll have no conflicts of interest to disclose.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. No animals were involved in the study. Informed consent was obtained from all patients for being included in the study.