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Authors
Yu, Hanyang
Hu, Rurui
He, Jianxin
Tian, Xinlun
Zhang, Ting
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Funding
Funding for this research was provided by:
National High Level Hospital Clinical Research Funding (2022-PUMCH-B-107)
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Article History
Received: 4 May 2025
Accepted: 16 March 2026
First Online: 6 April 2026
Declarations
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: The authors declare no competing interests.
: In this study, apart from conventional biochemical methods, we utilized AlphaFold 3 (AF3) to assist in molecular structure prediction. AF3 was applied to simulate and predict structural changes associated with NCF2 mutation in our patient. With the predicted complex derived from AF3, we further analyzed the possible spatial interference of the NADPH oxidase complex with mutated NCF2.
