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Article History

Received: 25 March 2021

Accepted: 8 November 2021

First Online: 3 January 2022

Declarations

:

: We try to replace live animals with unconscious experimental materials, or use lower animals to replace higher animals. we try to use the smallest number of animals to get the same amount of experimental data or use a certain number of animals to get more experimental data. We minimize the scope and extent of the impact of inhumane procedures on animals. All the preformation conducted in this present research was approved by the Animal Ethics Committee of Affiliated Hospital of Nanjing University (Nanjing, China) with the No. 20200233.

: Not applicable.

: Written informed consent for publication was obtained from all participants.

: All authors declare that there is no conflict of interest regarding the publication of this paper.