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Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology

Crossref DOI link: https://doi.org/10.1007/s10911-020-09466-z

Published Online: 2020-11-20

Published Print: 2020-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Martin Carli, Jayne F. https://orcid.org/0000-0002-2568-2912
Trahan, G. Devon https://orcid.org/0000-0002-0940-0794
Jones, Kenneth L. https://orcid.org/0000-0003-4572-3651
Hirsch, Nicole

Rolloff, Kristy P.

Dunn, Emily Z.

Friedman, Jacob E. https://orcid.org/0000-0002-6426-1512
Barbour, Linda A. https://orcid.org/0000-0001-8656-3995
Hernandez, Teri L. https://orcid.org/0000-0002-7024-5017
MacLean, Paul S. https://orcid.org/0000-0002-1123-6612
Monks, Jenifer https://orcid.org/0000-0002-7990-3389
McManaman, James L. https://orcid.org/0000-0003-4735-6429
Rudolph, Michael C. https://orcid.org/0000-0002-6147-212X
Funding

Funding for this research was provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520)

National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK007658-28)

National Institute of Diabetes and Digestive and Kidney Diseases (5R01DK101659)

National Institute of Diabetes and Digestive and Kidney Diseases (K01 DK109079)

National Institute of Diabetes and Digestive and Kidney Diseases (R03 DK122189-01)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (5T32HD007186-40)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01HD093729-02)

National Institute on Aging (U54 AG062319)

Colorado CCTSI (UL1 TR002535)
License Information

Text and Data Mining valid from 2020-11-20

Version of Record valid from 2020-11-20
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Article History

Received: 31 July 2020

Accepted: 27 October 2020

First Online: 20 November 2020

Compliance with Ethical Standards

:

: The authors declare that there are no conflicts of interest.

: (include appropriate approvals or waivers)Milk-derived cells were collected from deidentified samples obtained for Clinical Trial #NCT02244814. This trial was approved by the Colorado Multiple Institution Review Board (COMIRB #14–1538).

: (include appropriate statements)All participants gave their informed consent for milk collection and samples were deidentified prior to experimentation for this study.

: All authors declare their consent to the publication of this work.

: All code has been submitted in the supplemental methods file (“Martin_Carli_MEC_scRNA-seq_Markdown.html”).

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