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Article History

Received: 11 April 2019

Accepted: 23 November 2020

First Online: 6 January 2021

Compliance with ethical standards

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: The authors declare that they have no conflict of interest.

: Since all datasets included in this article were either from public databases or from previously published studies additional approval by an ethics committee was unnecessary. All human samples were acquired in the context of a prior project entitled 12CHN-204 PROMISE (Bilateral Greece-China Research Program of the Hellenic General Secretariat of Research and Technology and the Chinese Ministry of Research and Technology entitled “Personalization of melanoma therapeutic management through the fusion of systems biology and intelligent data mining methodologies-PROMISE”, sponsored by the Program “Competitiveness and Entrepreneurship”, Priority Health of the Peripheral Entrepreneurial Program of Attiki), under the strict conformity to the rules of the call. All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”