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Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Crossref DOI link: https://doi.org/10.1007/s10928-025-09963-w

Published Online: 2025-02-08

Published Print: 2025-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

van Valkengoed, Daan W. https://orcid.org/0009-0006-7830-2553
Hirasawa, Makoto https://orcid.org/0000-0002-1678-8539
Rottschäfer, Vivi https://orcid.org/0000-0002-4150-3486
de Lange, Elizabeth C. M. https://orcid.org/0000-0001-8303-1117
Funding

Funding for this research was provided by:

European Union’s Horizon 2020 research and innovation programme (848068)
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Text and Data Mining valid from 2025-02-08

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Article History

Received: 19 July 2024

Accepted: 16 January 2025

First Online: 8 February 2025

Declarations

:

: M.H. is an employee of Daiichi-Sankyo Co., Ltd. The other authors declare no conflicts of interest.

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