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Interplay between pharmacokinetics and immunogenicity of therapeutic proteins: stepwise development of a bidirectional joint pharmacokinetics-anti-drug antibodies model

Crossref DOI link: https://doi.org/10.1007/s10928-025-09971-w

Published Online: 2025-05-21

Published Print: 2025-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

van der Walt, Jan-Stefan

Wilkins, Justin

Khandelwal, Akash

Venkatakrishnan, Karthik

Gao, Wei

Milenković-Grišić, Ana-Marija
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Text and Data Mining valid from 2025-05-21

Version of Record valid from 2025-05-21
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Article History

Received: 6 December 2024

Accepted: 27 March 2025

First Online: 21 May 2025

Declarations

:

: JSvdW and JJW were employed as consultants by Merck KGaA when analyses were performed. AK was an employee of the healthcare business of Merck KGaA, Darmstadt, Germany at time of the analysis. KV is an employee of EMD Serono, Billerica, MA, USA. WG was an employee of EMD Serono, Billerica, MA, USA at time of the analysis. AMM is an employee of the healthcare business of Merck KGaA, Darmstadt, Germany.

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