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Scalable and Sustainable DMF-Free Solid-Phase Synthesis of Liraglutide by 1-Tert-Butyl-3-Ethylcarbodiimide-Mediated Couplings and Catch-and-Release Acylation and Purification Strategies

Crossref DOI link: https://doi.org/10.1007/s10989-025-10703-4

Published Online: 2025-02-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Pacini, Lorenzo

Muthyala, Manoj Kumar

Zitterbart, Robert

Marder, Oleg

Rovero, Paolo

Papini, Anna Maria
License Information

Text and Data Mining valid from 2025-02-22

Version of Record valid from 2025-02-22
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Article History

Accepted: 10 February 2025

First Online: 22 February 2025

Declarations

:

: Manoj Kumar Muthyala and Robert Zitterbart are employers of Gyros Protein Technologies Inc. and declare competing financial interests: the PurePep® Chorus synthesizer and the PurePep EasyClean technology described in the manuscript can be purchased from Gyros Protein Technologies. Oleg Marder is an employer of Luxembourg Bio Technologies and declare competing financial interests: T-Bec® described in the manuscript can be purchased from Luxembourg Bio Technologies.

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