One-pot synthesis of novel (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl) pyrrolidine-2-carboxamides via
$$\hbox {TiO}_{2}$$
TiO
2
-NPs and
$$\hbox {Pd}(\hbox {PPh}_{3})_{2}\hbox {Cl}_{2}$$
Pd
(
PPh
3
)
2
Cl
2
catalysts and investigation of their biological activities