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Structural disruption of VKORC1 by resistance mutations reveals a conserved hydrophobic pattern essential for warfarin binding: insights from molecular dynamics analyses

Crossref DOI link: https://doi.org/10.1007/s11030-026-11611-5

Published Online: 2026-06-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Chatron, Nolan https://orcid.org/0000-0002-7973-4896
Soro, Sionfoungo Daouda https://orcid.org/0009-0008-0429-2465
Benoit, Etienne https://orcid.org/0000-0002-7076-2911
Lattard, Virginie https://orcid.org/0000-0002-3371-0952
Funding

Funding for this research was provided by:

Agence Nationale de la Recherche (ANR-18-CE20-0025)

Agence Nationale de la Recherche (ANR-18-CE20-0025)

Agence Nationale de la Recherche (ANR-18-CE20-0025)

Agence Nationale de la Recherche (ANR-18-CE20-0025)
License Information

Text and Data Mining valid from 2026-06-04

Version of Record valid from 2026-06-04
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Article History

Received: 13 February 2026

Accepted: 23 May 2026

First Online: 4 June 2026

Declarations

:

: The authors declare no conflict of interest.

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