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Article History

Received: 19 April 2026

Accepted: 1 June 2026

First Online: 8 June 2026

Declarations

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: All animal experiments complied with the ARRIVE guidelines and National Institutes of Health guide for the care and use of Laboratory animals. 6-week female nude mice were used in the xenograft model. The animal experiment was approved by Medical Ethics and Experimental Animal Welfare Committee at Henan University School of Medicine (Reference No.: HUSOM2025-014). Human sample usage was authorized by the Medical and Scientific Research Ethics Committee of Kaifeng Central Hospital (Approval No.: 2021LL012-KFZXYY, obtained at July 28th, 2021). All procedures followed the relevant regulations and guidelines. Because this study does not follow the clinical trial design, the requirement for a clinical trial registration number is not applicable. All participants or their legal guardians provided informed consent to publish potentially identifiable information in this study.

: While preparing this manuscript, the author applied a large language model (DeepSeek) to polish the language and reduce overall similarity with the previously published preprint version [ ]. The author has reviewed and edited the AI-processed version and assumes complete responsibility for the content of the published article.

: The authors declare no competing interests.