Ando, Shiori
Funato, Michinori
Ohuchi, Kazuki
Inagaki, Satoshi
Sato, Arisu
Seki, Junko
Kawase, Chizuru
Saito, Toshio
Nishio, Hisahide
Nakamura, Shinsuke
Shimazawa, Masamitsu
Kaneko, Hideo
Hara, Hideaki
Article History
Received: 15 November 2018
Revised: 4 April 2019
Accepted: 9 May 2019
First Online: 17 May 2019
Compliance with Ethical Standards
:
: The authors declare that there are no conflicts of interest.
: The procedures used in the experiments on human induced pluripotent stem cells (Control iPSCs; 201B7 line) adhered to the tenets of the Declaration of Helsinki. The 201B7 line was generated from adult human dermal fibroblasts which was purchased from Cell Applications, Inc (San Diego, CA, USA) [CitationRef removed]. The somatic cells collection from the patients, the establishment of patient-derived iPSCs, and pathological analysis of differentiated iPSCs including evaluation of the potential drug efficacy were planned in this study. These planed protocols were approved by the Ethics Review Committee of the National Hospital Organization, Nagara Medical Center (Approval Number: 26-15), and informed consents were obtained from the parents of our pediatric patients. Informed consents were obtained from the subjects after explanation of the nature and possible consequences of the study.