Qiu, Yanying
Yin, Qiyang
Fei, Yuxiang
Li, Yize
Huang, Hongfei
Fang, Weirong
Shen, Weiyang
Liang, Bingwen
Zhu, Xiong
Li, Yunman http://orcid.org/0000-0001-5565-3322
Funding for this research was provided by:
National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Thirteenth Five-year Plan Period (2018ZX09301043-00, 2016ZX09101031)
The “Double First-Class” Construction Technology Innovation Team Project of China Pharmaceutical University (CPU2018GY23)
Article History
Received: 15 February 2019
Revised: 13 May 2019
Accepted: 10 June 2019
First Online: 15 June 2019
Compliance with Ethical Standards
:
: The authors declare that they have no conflict of interest
: SPF male SD rats were purchased from Qinglongshan Animal Farm (Nanjing, China, license number: SYXK (Su) 2017-0001). Rats were housed in coops on a 12 h light–12 h dark schedule at the controlled temperature of 23 ± 2.5 °C with free access to a normal diet and tap water. All animals were cared for and treated according to institutional guidelines of China Pharmaceutical University, which conforms to the European Community guidelines (EEC Directive of 1986: 86/609/EEC). Efforts were made to minimize the number of rats and their suffering.