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Authors
Zheng, Yuanzi
Ma, Yanjun
Pan, Yuhang
Ali, Tahir
Zheng, Chengyou
Miu, Kelvin Kaikei
Wang, Zhangting
Zhang, Limeng
Li, Shupeng
Tan, Zhen
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Funding
Funding for this research was provided by:
Science and Technology Program of Nanshan District, Shenzhen (NS2023128, NS2023128)
Medicine Plus Program of Shenzhen University (2024YG011, 2024YG011)
Education Reform Project of Guangdong Province (2021JD082, 2021JD082)
Tianfu Jincheng Laboratory (Frontier Medical Center) results transformation funding project, (2025ZH047)
HaiYa Young Scientist Foundation of Shenzhen University General Hospital; Shenzhen Health Elite Talents (2021XKQ193)
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Article History
Received: 8 June 2025
Revised: 10 August 2025
Accepted: 14 August 2025
First Online: 4 September 2025
Declarations
:
: The authors declare no competing interests.
: Not applicable.
: Not applicable.
: Not applicable.
: This manuscript presents a narrative review synthesizing current evidence on the interplay between antidepressant mechanisms and autophagy modulation in depression. A comprehensive literature search was conducted across PubMed, Web of Science, and Google Scholar, focusing on peer-reviewed articles published in English.Search StrategyKey Terms Included Core concepts: “Autophagy,” “Antidepressants,” “Depression,” “Neuroinflammation.”Mechanistic Terms “Autophagosome formation,” “Autophagy flux,” “mTOR signaling,” “Lysosomal degradation,” “Mitophagy.” “Major Depressive Disorders.”Drug Classes “SSRIs,” “SNRIs,” “Tricyclic antidepressants” “Atypical antidepressants,
: Studies were prioritized based on: Relevance to autophagy dysregulation in depressive pathology. Evidence linking antidepressant effects to autophagy pathways (e.g., mTOR, AMPK, Beclin-1). Preclinical (animal/cell models) and clinical findings.
: Extracted data were analyzed to identify: Convergent mechanisms of autophagy modulation by antidepressants. Gaps in translational research (e.g., biomarker development, cell-type-specific effects).
