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Roflumilast Elicits Therapeutic and Neuroprotective Effects in 3-Nitropropionic Acid-Induced Huntington’s Disease-Like Neurodegeneration in Rats by Mitigating NLRP3 Inflammasome-Mediated Pyroptosis, Ferroptosis, and Glial Activation

Crossref DOI link: https://doi.org/10.1007/s11064-026-04682-1

Published Online: 2026-02-28

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Taha, Mohamed

Salah, Dalia

Abdou, Kareem

Senousy, Mahmoud A.
Funding

Funding for this research was provided by:

Cairo University
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Text and Data Mining valid from 2026-02-28

Version of Record valid from 2026-02-28
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Article History

Received: 9 August 2025

Revised: 29 December 2025

Accepted: 20 January 2026

First Online: 28 February 2026

Declarations

:

: The authors declare no competing interests.

: This study acquired an approval number: BC3524 from the institutional review board, the Ethics Committee for Experimental and Clinical Studies, Faculty of Pharmacy, Cairo University, Cairo, Egypt, which approved all experimental protocols and animal procedures.

: Not applicable.

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