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In vitro Stability Study of a Panel of Commercial Antibodies at Physiological pH and Temperature as a Guide to Screen Biologic Candidate Molecules for the Potential Risk of In vivo Asparagine Deamidation and Activity Loss

Crossref DOI link: https://doi.org/10.1007/s11095-025-03825-3

Published Online: 2025-02-20

Published Print: 2025-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Garg, Richa

McCarthy, Sean

Thompson, Alayna George

Zhang, Jiang

Mattson, Emily

Clabbers, Anca

Acquah, Aimalohi

Xu, Jianwen

Zhou, Chen

Ali, Amr

Filoti, Dana

Singh, Rajeeva https://orcid.org/0000-0002-1537-6209
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Text and Data Mining valid from 2025-02-01

Version of Record valid from 2025-02-20
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Article History

Received: 11 November 2024

Accepted: 19 January 2025

First Online: 20 February 2025

Declarations

:

: AbbVie funded the study and participated in study design, research, data collection, analysis and interpretation of data, writing, reviewing, and approving the publication. Jianwen Xu has no additional conflicts of interest to report and is currently affiliated with Kiniksa Pharmaceuticals. Richa Garg, Sean McCarthy, Alayna George Thompson, Jiang Zhang, Emily Mattson, Anca Clabbers, Aimalohi Acquah, Chen Zhou, Amr Ali, Dana Filoti, Rajeeva Singh are employees of AbbVie and may own AbbVie stock.

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