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Article History

Accepted: 12 November 2022

First Online: 10 December 2022

Declarations

:

: During development of the manuscript, a contract research organization. FB is employed by and own equity in Quantify Research, a contract research organization. JAK received consultancies/speaking fees from AgNovos healthcare, Amgen, D3A, Lilly, Medimaps, Unigene, Radius Health, Pfizer, Servier, and Takeda; and research support from Asahi, Amgen, GSK, Lilly, Medtronic, Novartis, Pfizer, Sanofi-Aventis, Servier, and Warner Chilcott. EM received consultancies, honoraria and speaking fees from Active Signal, Alliance for Better Bone Health, Amgen, Bayer, Boehringer Ingelheim, Consilient Healthcare, Eli Lilly, GE Lunar, GSK, Hologic, Internis, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, Synexus, Tethys, and UCB; and research funding from the Alliance for Better Bone Health, Amgen, Arthritis Research UK, EPSRC, Internis, Medical Research Council, and NIHR. HPD reports consultancies, honoraria and speaking fees from Amgen, BRAINCON, Daiichi-Sankyo, Eli Lilly, Merck Sharp & Dohme, Novartis, Nycomed, Servier, Sinapharm, Alexion, Daiichi-Sankyo, Genericon, Kyphon, and Genericon. TT reports consultancies, honoraria and speaking fees, and grants from Abbvie, Amgen, BMS, Chugai/Roche, Eli Lilly, Expanscience, Gilead, Merck Sharp & Dohme, Medac, Thuasne, UCB, HAC-Pharma, LCA, Novartis, Pfizer, Servier, and TEVA. The remaining authors report no conflict of interest.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethics approval were obtained for all countries with the following record identification numbers: Australia (Barwon health human ethics research committee) BH HREC 09/49; Austria (Medical University of Graz) 18-001 ex 06/07; Estonia (University of Tartu) 192/T-4; France (Commission NAtionale de l’informatique et des Libertes /Direction Generale del la Recherce et de l’innovation) AT/YPA/SV/SN/GDP/EM/AR081020; Lithuania (Lithuanian Bioethics Committee) 2007-06-21 Nr. 16; Italy (Istituto Auxologico Italiano) 02A603; Mexico (Hospital Infantil de Mexico Federico Gómez) FMED/CI/GRD/042/06/2008; Russia (Ural State Medical University) 1.14.03.2007; Spain (Institut Municipal d’Assistencia Sanitaria, Barcelona) 26/09/2007; UK (South Yorkshire Research Ethics Committee): 09/H1310/53.

: Informed consent was obtained from all individual participants included in the study and all study participants could with draw from the study at any time at their own request.