Funding for this research was provided by:
Fundação de Amparo à Pesquisa do Estado de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Pesquisa (CNPQ) - Brasil
Text and Data Mining valid from 2019-03-16
First Online: 16 March 2019
Compliance with ethical standards
: R.H.M. Furtado: Honoraria: AstraZeneca; Research Grant: AstraZeneca, DalCor, Boehinger, Pfizer, Bayer, Sanofi. R.P. Giugliano: Research Grant: Amgen, Merck. Honoraria; Significant; Amgen, Daiichi Sankyo, Merck. Consultant/Advisory Board; Significant; Amarin, Amgen, Boehringer- Ingelheim, Bristol-Myers-Squibb, CVS Caremark, Daiichi Sankyo, GlaxoSmithKline, Lexicon, Merck, Portola, Pfizer. T.F. Dalcoquio: Travel grant: Bayer; Research Grant: AstraZeneca, DalCor P.R.R. Genestreti: Advisory board: NovoNordisk, Sanofi, AstraZeneca; Speaker board: NovoNordisk, Sanofi, AstraZeneca, Boeringher-Ingelhbeim, Eli-Lilly, L.M. Baracioli: Research Grant: AstraZeneca, DalCor J.C. Nicolau: Research Grant: Sao Paulo Research Foundation, Amgen Inc., Bayer Healthcare Pharmaceuticals, Bristol-Myers Squibb Company, DalCor, Janssen Pharmaceuticals Inc, Sanofi-Aventis, Astra Zeneca, Boehringer Ingelheim, Novartis, Pfizer Inc. Consultant/Advisory Board; Significant; Sanofi-Aventis. All other co-authors have nothing to disclose.
: Patients with stable CAD were enrolled from two randomized clinical trials (NCT02389582 and NCT 01896557) and one case-control study conducted at our institution. These three studies were approved by our institutional review board and all patients signed informed consent form (ICF) before obtaining blood test for assessment of platelet aggregation or serum TXB2 dosage. In the case of patients with ACS, platelet aggregation was obtained in a routine basis at the CCU discharge and, because of that, ICF was waived according to local regulations. All data from this report were analyzed by two independent authors (RHMF and RS) using de-identified patient information.