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Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster

Crossref DOI link: https://doi.org/10.1007/s11306-024-02153-8

Published Online: 2024-08-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ayon, Navid J. https://orcid.org/0000-0001-5546-912X
Earp, Cody E. https://orcid.org/0000-0003-2826-0480
Gupta, Raveena

Butun, Fatma A.

Clements, Ashley E.

Lee, Alexa G.

Dainko, David

Robey, Matthew T.

Khin, Manead https://orcid.org/0000-0002-5744-9584
Mardiana, Lina https://orcid.org/0000-0002-6639-4634
Longcake, Alexandra https://orcid.org/0000-0003-2881-3938
Rangel-Grimaldo, Manuel https://orcid.org/0000-0003-1261-3317
Hall, Michael J. https://orcid.org/0000-0001-6475-9161
Probert, Michael R. https://orcid.org/0000-0002-2412-7917
Burdette, Joanna E. https://orcid.org/0000-0002-7271-6847
Keller, Nancy P. https://orcid.org/0000-0002-4386-9473
Raja, Huzefa A. https://orcid.org/0000-0002-0824-9463
Oberlies, Nicholas H. https://orcid.org/0000-0002-0354-8464
Kelleher, Neil L. https://orcid.org/0000-0002-8815-3372
Caesar, Lindsay K. https://orcid.org/0000-0002-1243-6923
Funding

Funding for this research was provided by:

National Science Foundation (REU CHE-2150091)

Engineering and Physical Sciences Research Council (EP/W021129/1)

National Institutes of Health (R01 GM112739-05A1, P01 CA125066, 2R01 AT009143, F32 GM132679)
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Text and Data Mining valid from 2024-08-02

Version of Record valid from 2024-08-02
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Article History

Received: 9 April 2024

Accepted: 16 July 2024

First Online: 2 August 2024

Declarations

:

: The authors declare financial conflicts of interest with MicroMGx (N.L.K.) and Terra Bioforge (N.L.K., N.P.K.). Further, N.L.K. is a consultant for Thermo Fisher Scientific focusing on the use of Fourier-transform Mass Spectrometry in multi-Omics research. N.H.O. and H.A.R. are on the Scientific Advisory Board of Clue Genetics, and N.H.O. is on the Scientific Advisory Boards of Mycosynthetix, Inc. and Ionic Pharmaceuticals, LLC. M.J.H. and M.R.P. are directors and shareholders, whilst L.M. and A.L. are employees of Indicatrix Crystallography. The remaining authors declare no competing interests.

: This article does not contain any studies with human and/or animal participants performed by any of the authors.

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