Rubins, Daniel J. https://orcid.org/0000-0002-1587-6190
Meng, Xiangjun
Wang, Shubing
Haley, Hyking https://orcid.org/0000-0001-6705-2276
Posavec, Diane
Purcell, Mona https://orcid.org/0000-0002-1339-3611
Riffel, Kerry
Myers, Robert W.
Sebhat, Iyassu K. https://orcid.org/0000-0002-9506-1388
Trotter, Dinko Gonzalez https://orcid.org/0009-0005-5862-403X
Klimas, Michael https://orcid.org/0000-0002-5043-550X
Holahan, Marie https://orcid.org/0000-0001-7514-6176
Article History
Received: 29 July 2025
Revised: 21 November 2025
Accepted: 11 December 2025
First Online: 22 December 2025
Declarations
:
: All procedures involving animals were conducted at Merck & Co., Inc. (Rahway, NJ, USA) under the guiding principles of the American Physiological Society and the Guide for the Care and Use for Laboratory Animals published by the US National Institutes of Health (NIH publication No 85–23, revised 1985) and were approved by the Institutional Animal Care and Use Committee at Merck & Co., Inc. (Rahway, NJ, USA).
: This work was entirely funded by Merck & Co., Inc. The authors have no relevant financial or non-financial interests to disclose, other than employment at Merck & Co., Inc. at the time of this work. The authors also declare that they have no competing interests.