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Article History

Received: 17 March 2020

Revised: 9 July 2020

Accepted: 1 August 2020

First Online: 22 August 2020

Compliance with ethical standards

:

: The study protocol has been approved by the research institute´s committee on human research (AZ 2017-750-f-S). Subjects gave their written consent.

: JS is supported by the Kommission für Innovative Medizinische Forschung an der Medizinischen Fakultät Muenster (IMF Grant SP 11 18 15), the Deutsche Herzstiftung (DHS Grant S/01/19), the young investigator research from Scuola Superiore Sant’Anna Pisa (Curriculum Ph.D. in Translational Medicine) and has received travel grants and lecture honoraria from Boehringer Ingelheim and Chiesi (all) outside the present work. MB has been supported by Sanofi Genzyme and Löwenstein Medical outside this work. MB has received speaker honoraria and travel grants from Sanofi Genzyme, UCB Pharma and Löwenstein Medical outside this work. MD reports to have received travel grants and/or speaking fees and/or fees for consulting from Actelion, Astra Zeneca, Bayer, Berlin Chemie, Boehringer, Chiesi, GSK, Hamilton, Heinen und Löwenstein, Intermune, Linde, Novartis, Pfizer, Philips Respironics, ResMed, Roche and Weinmann outside the present workAG, HS, BB, PS, CP, ME, HS, WR, MM, CT and AB declare no conflicts of interest in the context of the present study.

: The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.