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Early loss of astrocyte p38α MAPK reduces hippocampal neuroinflammation, enhances synaptic strength, and increases non-synaptic mitochondrial uncoupling in female mice during non-pathological aging

Crossref DOI link: https://doi.org/10.1007/s11357-025-01948-4

Published Online: 2025-11-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bailey, Caleb S.

Gant, John C.

Frazier, Hilaree N.

Morganti, Josh M.

Coleman, Meggie C.

Davis, Verda A.

J. Vekaria, Hemendra

G. Sullivan, Patrick

Norris, Christopher M.

Van Eldik, Linda J.

Braun, David J. https://orcid.org/0000-0002-6967-0489
Funding

Funding for this research was provided by:

National Institute on Aging (RF1 AG064859, T32 AG078110, P30 AG072946, P01AG078115, R01AG070830, RF1NS118558)

BrightFocus Foundation (A2024039S)

National Institute of General Medical Sciences (P20GM1483267)
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Text and Data Mining valid from 2025-11-14

Version of Record valid from 2025-11-14
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Article History

Received: 7 July 2025

Accepted: 8 October 2025

First Online: 14 November 2025

Declarations

:

: The authors declare no competing interests.

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