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Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood–brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain

Crossref DOI link: https://doi.org/10.1007/s11357-025-01986-y

Published Online: 2026-01-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Otu-Boakye, Sarah

Natarajan, Duraipandy

Plakkot, Bhuvana

Raghavendiran, Ilakiya

Hoppa, Paulina

Kiss, Tamas

Subramanian, Madhan

Balasubramanian, Priya https://orcid.org/0000-0003-0912-5363
Funding

Funding for this research was provided by:

National Institute on Aging (R03AG095868)

National Institute on Aging (K01AG073613)

National Heart, Lung, and Blood Institute (R01HL163775)

American Heart Association (CDA1048544)

Presbyterian Health Foundation

American Federation for Aging Research
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Text and Data Mining valid from 2026-01-16

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Article History

Received: 10 September 2025

Accepted: 24 October 2025

First Online: 16 January 2026

Declarations

:

: The authors declare no competing interests.

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