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Genetic deletion of adenosine A2A receptors attenuates memory deterioration and alterations of synaptic plasticity and metabolic controllers in the hippocampus and prefrontal cortex of aged mice

Crossref DOI link: https://doi.org/10.1007/s11357-026-02219-6

Published Online: 2026-03-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lopes, Cátia R.

Madeira, Daniela

Piteira, Madalena

Valada, Pedro

Santos, Joana

Silva, Henrique B.

Gonçalves, Francisco Q.

Tomé, Ângelo R.

Canas, Paula M.

Lopes, João Pedro

Ferreira, Samira G.

Agostinho, Paula

Cunha, Rodrigo A. https://orcid.org/0000-0003-2550-6422
Funding

Funding for this research was provided by:

Programa Operacional Regional do Centro (CENTRO-01-0246-FEDER-00001)

Fundação para a Ciência e a Tecnologia (COMPETE2030-FEDER-0067630)

Universidade de Coimbra
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Article History

Received: 10 December 2025

Accepted: 12 March 2026

First Online: 30 March 2026

Declarations

:

: Experiments were conducted in agreement with European legislation (Directive 2010/63/EU) and the Portuguese law on animal care (113/2013) after approval by the Institution's Ethical Committee (ORBEA_300/2021; DGAV018449) and certification by Direção Geral de Alimentação e Veterinária (018449, 29–11-2021).

: RAC is a scientific consultant of the Institute for Scientific Information on Coffee (ISIC). All other authors report no conflicts of interests.

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