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Potent SARS-CoV-2 3C-like protease inhibitor ( +)-eupenoxide-3,6-diketone (IC50: 0.048 μM) was synthesized based on ( +)-eupenoxide; lead from ( +)-eupenoxide analogs study by endophytic fermentation

Crossref DOI link: https://doi.org/10.1007/s11418-024-01874-3

Published Online: 2025-02-03

Published Print: 2025-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Maehara, Shoji https://orcid.org/0000-0001-5787-6546
Kumamoto, Moeka

Nakajima, Shogo

Hieda, Yuhzo

Watashi, Koichi

Hata, Toshiyuki
Funding

Funding for this research was provided by:

Japan Science and Technology Corporation (JPMJSC15H1, JPMJSC15H1)

JST-Mirai Program (JPMJMI22G1)

Japan Society for the Promotion of Science (23K06189, 24K02290)

Japan Agency for Medical Research and Development (JP23fk0108590)
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Text and Data Mining valid from 2025-02-03

Version of Record valid from 2025-02-03
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Article History

Received: 24 November 2024

Accepted: 21 December 2024

First Online: 3 February 2025

Declarations

:

: The authors declare no conflicts of interest associated with this manuscript.

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