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Article History

Received: 23 December 2025

Accepted: 18 February 2026

First Online: 3 March 2026

Declarations

:

: The authors have no relevant financial or non-financial interests to disclose.

: All animal procedures were approved by the Animal Experiment Committee of Kumamoto University (A 2025-083 R1) and were conducted in accordance with institutional guidelines for the care and use of laboratory animals.

: / Consent for publication .

: Not applicable.

: During preparation of this manuscript, the authors used ChatGPT (OpenAI) to assist with language editing and restructuring of the text. All suggestions from the tool were checked, edited, and approved by the authors, who take full responsibility for the content of the article.