Pradhan, Suraj S.
Salinas, Kirstie
Garduno, Alexis C.
Johansson, Jenny U.
Wang, Qian
Manning-Bog, Amy
Andreasson, Katrin I.
Funding for this research was provided by:
National Institute of Neurological Disorders and Stroke (1F31NS074712 - 01A1)
National Science Foundation (2008070772)
National Institutes of Health (R01 AG030209)
Article History
Received: 3 October 2016
Accepted: 4 October 2016
First Online: 12 October 2016
Compliance with Ethical Standards
:
: The authors declare that they have no conflict of interest.
: SSP designed and performed all MPTP and cell culture experiments, and prepared the manuscript. KS performed ELISA analysis of conditioned media from microglia and BV2 cells. ACG assisted with sectioning of brains, and immunostaining and image analysis of brain sections. JUJ performed isolation of the peritoneal macrophages used in this study and assisted in gene expression analysis. QW assisted with logistics of various experiments, in particular the luminex analysis of conditioned media from microglia. NK performed HPLC analysis of dopamine and associated metabolites from striatal brain sections. AMB collaborated on this study by lending stereology and HPLC equipment from her lab and advised in the design of experiments. KIA provided the resources to conduct the majority of experiments, and provided guidance on experimental design and manuscript preparation. All authors have read and approved the final version of the manuscript.