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Article History

First Online: 18 September 2019

Compliance with Ethical Standards

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: Medical writing support for this review was provided by ClinicalThinking and funded by Merck KGaA and Pfizer, Inc.

: Petros Grivas reports a consulting/advisory role for AstraZeneca, Bayer, Biocept, Bristol-Myers Squibb, Clovis Oncology, Dendreon, Driver Inc., EMD Serono, Exelixis, Foundation Medicine, Genentech, Genzyme, Heron Therapeutics, Janssen, Merck & Co., Mirati Therapeutics, Pfizer, QED Therapeutics, and Seattle Genetics; a speaker’s role (educational, unbranded program) for Bristol-Myers Squibb and Genentech; travel support from AstraZeneca and Clovis Oncology; and institutional research funding (for clinical trials) from AstraZeneca, Bavarian Nordic, Bayer, Bristol-Myers Squibb, Clovis Oncology, Debiopharm, Genentech, Immunomedics, Merck & Co., Mirati Therapeutics, Oncogenex, and Pfizer. Bradley Monk reports a consulting/advisory role for Advaxis, Aravive, Geistlich, Genmab, ImmunoGen, Mateon, Merck, Myriad, Perthera, Pfizer, Takeda, and VBL Therapeutics; and a speaker’s role for AstraZeneca, Clovis, Janssen/Johnson & Johnson, Roche/Genentech, and TESARO Incorporated. Daniel Petrylak reports a consulting/advisory role for Bayer, Bellicum, Dendreon, Sanofi, Johnson & Johnson, Exelixis, Ferring, Millennium, Medivation, Pfizer, Roche, and Tyme Pharmaceuticals; research funding from Agenysis, Celgene, Dendreon, Eli Lilly, Johnson & Johnson, Millineum, Oncogenix, Progenics, Roche, and Sanofi; and expert testimony for Sanofi. Martin Reck reports a consulting/advisory role for AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly, Merck, Merck Sharpe & Dohme, Novartis, Pfizer, and Roche; and a speaker’s role for AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly, Merck, Merck Sharpe & Dohme, Novartis, Pfizer, and Roche. Grace Foley and Constantin Makris are employed by Pfizer Inc. Silke Guenther is employed by Merck KGaA. Dan Hennessy is employed by EMD Serono (a business of Merck KGaA). Markus Moehler reports a consulting/advisory role for Amgen, Bayer, Bristol-Myers Squibb, Eli Lilly, Merck, Merck Sharpe & Dohme, Onyx, Pfizer, and Roche; research funding from AIO-Studien-gGmbH, Amgen, Bristol-Myers Squibb, European Organisation for Research and Treatment of Cancer, Merck, Merck Sharp & Dohme, Roche, Taiho Pharmaceutical, and Transgene; and honoraria from American Society of Clinical Oncology, Amgen, Bristol-Myers Squibb, Eli Lilly, European Society for Medical Oncology, Falk, Merck, Nordic, and Pfizer.