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Article History

Accepted: 2 March 2022

First Online: 2 April 2022

Declarations

:

: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

: Takuro Mizukami has received grants from Taiho Pharma, Eli Lilly Japan, and Ono Pharma, and have received honoraria from Taiho Pharma, Chugai Pharma, Bayer Pharma, Merk Serono Pharma, Takeda Pharma, Eli Lilly Japan, Asahi Kasei Pharma Corporation, Otsuka Pharma, Bristol-Myers Squibb, and Ono Pharma. Tomoyo Oguri is an employee of Astra Zeneca K.K. Hiroyuki Takeda, Kiyomi Imoto, Kumiko Umemoto, Ayako Doi, Hiroyuki Arai, Yoshiki Horie, Takashi Ogura, Naoki Izawa, Hiroyuki Yamamoto, Yoshihisa Yamano, and Yu Sunakawa declare that they have no conflicts of interest that might be relevant to the contents of this article.

: This study was approved by the Ethics Committee of St. Marianna University School of Medicine.

: All patients provided written informed consent for genomic analysis and use of their data.

: Not applicable.

: Not applicable.

: Not applicable.

: HT and KI collected the data and performed the analyses. All authors interpreted the data, contributed to the writing and approved the final manuscript.