Choo, Joan R. E.
Jan, Yi-Hua
Ow, Samuel G. W.
Wong, Andrea
Lee, Matilda Xinwei
Ngoi, Natalie
Yadav, Kritika
Lim, Joline S. J.
Lim, Siew Eng
Chan, Ching Wan
Hartman, Mikael
Tang, Siau Wei
Goh, Boon Cher
Tan, Hon Lyn
Chong, Wan Qin
Yvonne, Ang Li En
Chan, Gloria H. J.
Chen, Shu-Jen
Tan, Kien Thiam
Lee, Soo Chin http://orcid.org/0000-0002-5835-6419
Funding for this research was provided by:
Singapore Ministry of Health’s National Medical Research Council (CGAug16M005, C/CSASI/0004/2015)
Article History
Accepted: 26 April 2022
First Online: 14 June 2022
Declarations
:
: This research was supported by the Singapore Ministry of Health’s National Medical Research Council under its Centre Grant (CG) Programme (CGAug16M005) and Clinician Scientist Award (SI Category, C/CSASI/0004/2015).
: Soo Chin Lee has received Honoraria and consulting fees from Astra Zeneca, Pfizer, Novartis, Eli Lilly, Roche, ACT Genomics, Eisai; research funding from Taiho, Eisai, Pfizer and ACT Genomics. Samuel GW Ow has received honoraria from AstraZeneca, Pfizer, Lilly, Roche and Novartis. Andrea Wong has received research funding from Otsuka Pharmaceuticals, and has advisory roles with Pfizer, Novartis and Eisai. Natalie Ngoi has received honoraria from AstraZeneca. Joline SJ Lim has consultancy with Pfizer, Novartis; research funding from Synthon. Goh Boon Cher has received honoraria from Novartis, Merck Serono, MSD; has consultancy with Adagene; research support and funding from Bayer, MSD, BMS, Adagene, and Taiho; stock interests in Gilead Sciences and Avantor. Yi-Hua Jan, Shu-Jen Chen and Kien Thiam Tan are under employment by ACT Genomics. Joan RE Choo, Matilda Xinwei Lee, Kritika Yadav, Siew Eng Lim, Ching Wan Chan, Mikael Hartman, Siau Wei Tang, Hon Lyn Tan, Wan Qin Chong, Ang Li En Yvonne, Gloria HJ Chan declared no conflicts of interest.
: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the National Healthcare Group Domain Specific Ethics Review Board in 2016 (DSRB 2016/00327).
: Signed written informed consent was obtained from all individual participants included in the study.
: All data generated or analyzed during this current study are included in this published article.
: Not applicable.
: All authors contributed to at least one of the following: study conception, design, data acquisition, analysis, and/or interpretation. The first draft of the manuscript was written by JC and supervision/critical revision of the work was done by LSC. All authors have read and approved the final manuscript.