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Article History

Accepted: 22 May 2023

First Online: 27 June 2023

Declarations

:

: Matteo Santoni has received research support and honoraria from Janssen, Bristol Myers Squibb, Ipsen, MSD, Astellas, and Bayer, all unrelated to the present paper. R. Kanesvaran has received fees for speaker bureau and advisory board activities from the following companies: Pfizer, MSD, BMS, Eisai, Ipsen, Johnson and Johnson, Merck, Amgen, Astellas, and Bayer. Enrique Grande has received honoraria for speaker engagements, advisory roles or funding of continuous medical education from Adacap, AMGEN, Angelini, Astellas, Astra Zeneca, Bayer, Blueprint, Bristol Myers Squibb, Caris Life Sciences, Celgene, Clovis-Oncology, Eisai, Eusa Pharma, Genetracer, Guardant Health, HRA-Pharma, IPSEN, ITM-Radiopharma, Janssen, Lexicon, Lilly, Merck KGaA, MSD, Nanostring Technologies, Natera, Novartis, ONCODNA (Biosequence), Palex, Pharmamar, Pierre Fabre, Pfizer, Roche, Sanofi-Genzyme, Servier, Taiho, and Thermo Fisher Scientific. EG has received research grants from Pfizer, Astra Zeneca, Astellas, and Lexicon Pharmaceuticals. Tomas Buchler has received research support and honoraria from Roche, Bristol Myers Squibb, Ipsen, Exelixis, Eisai, Merck Sharp Dohme, Merck, Eli Lilly, and AstraZeneca, all unrelated to the present paper. Aristotelis Bamias has received honoraria/advisory/research support by Pfizer, BMS, AZ, MSD, Roche, Janssen, Ipsen, Bayer, and Merck. Fernando Sabino Marques Monteiro has received research support from Janssen and Merck Sharp Dome and honoraria from Janssen, Ipsen, Bristol Myers Squibb, and Merck Sharp Dome. Camillo Porta has received honoraria from Angelini Pharma, AstraZeneca, BMS, Eisai, General Electric, Ipsen, and MSD and acted as a Protocol Steering Committee Member for BMS, Eisai, and MSD. The other authors declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

: No external funding was used in the preparation of this manuscript.

: This retrospective research was carried out in accordance with the approval from the ethics committee of the Marche Region (2021-492) and was performed in accordance with the Declaration of Helsinki.

: All data generated or analyzed during this study are included in this published article (and its supplementary information files). The datasets generated during and/or analyzed during the current study are not publicly available in accordance with all the centers participating to the ARON project but are available from the corresponding author on reasonable request.

: <i>Conceptualization:</i> Matteo Santoni, Camillo Porta, Gaetano Aurilio. <i>Data curation:</i> Matteo Santoni, Francesco Massari, Fernando Sabino M. Monteiro, Zin W. Myint, Umberto Basso, Jindrich Kopecky, Jakub Kucharz, Mimma Rizzo¹ Luca Galli, Thomas Büttner, Ugo De Giorgi, Ondřej Fiala, Paolo Andrea Zucali, Giuseppe Fornarini, Maria T Bourlon, Sarah Scagliarini, Javier Molina-Cerrillo, Marc R Matrana, Renate Pichler, Carlo Cattrini, Emmanuel Seront, Alvaro Pinto, Rossana Berardi, Anca Zgura, Giulia Mammone, Jawaher Ansari, Francesco Atzori, Rita Chiari, Orazio Caffo, Giuseppe Procopio, Maria Bassanelli, Sara Merler, Carlo Messina, Zsófia Küronya, Alessandra Mosca, Dipen Bhuva, Nuno Vau, Lorena Incorvaia, Sara Elena Rebuzzi, Giandomenico Roviello. <i>Formal analysis:</i> Matteo Santoni. <i>Investigation:</i> Francesco Massari. <i>Methodology:</i> Alessandro Rizzo, Ignacio Ortego Zabalza, Roberto Iacovelli, Martin Pichler. <i>Project administration:</i> Giulia Sorgentoni. <i>Supervision:</i> Enrique Grande, Aristotelis Bamias, Fabio Calabrò. <i>Roles/writing—original draft:</i> Matteo Santoni, Veronica Mollica, Sebastiano Buti. <i>Writing—review & editing:</i> Tomas Büchler, Ravindran Kanesvaran, Camillo Porta, Nicola Battelli, Rodolfo Montironi.