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Article History

Accepted: 21 May 2024

First Online: 19 June 2024

Declarations

:

: METSSAR was an investigator-initiated trial at Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Partial funding as well as investigational product support was provided by Karyopharm Therapeutics.

: A. Salawu has received research funding from PTC Therapeutics; speaker fees from Medison pharma; and advisory board/consulting fees from Boehringer Ingelheim, Amgen, Bayer, Astellas, Taiho, and Knight Therapeutics. G. Watson has received travel grants from Bristol Meyer Squibb, Abbvie; Honoraria from Pfizer, Astra Zeneca, Knight Therapeutics, Novartis, Boehringer Ingelheim, Gilead and advisory board/consulting fees from Novartis and Boehringer Ingelheim. A.R. Abdul Razak has received research funding from Boehringer Ingelheim, Deciphera, Karyopharm Therapeutics, Pfizer, Roche/Genentech, Bristol-Myers Squibb, MedImmune, Amgen, GlaxoSmithKline, Blueprint Medicines, Merck, Abbvie, Adaptimmune, Iterion Therapeutics, 23&Me, Rain Therapeutics, Neoleukin Therapeutics, Daiichi Sankyo, Symphogen, Frontier Therapeutics; and advisory board/consulting fees from Adaptimmune, Bayer, Boehringer Ingelheim, GlaxoSmithKline, Medison, Inhibrx; and payment for expert testimony from Medison. E.R. Malone, E. Al-Ezzi, S. Genta, O. Vornicova, L. Wang, L. Arones, M. Phillips, J. Lee, and A.A. Gupta declare that they have no conflicts of interest that might be relevant to the contents of this article.

: The study protocol was approved by the Research Ethics Board (REB) at the Princess Margaret Cancer Centre, Toronto. All participants gave written informed consent, and the trial was performed in compliance with the Declaration of Helsinki and Good Clinical Practice guidelines.

: Not applicable.

: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: Conception and design of study: A.R. Abdul Razak, E.R. Malone. Acquisition of data: A. Salawu, E. Al-Ezzi, S. Genta, O. Vornicova, L. Wang, L. Arones, M. Phillips, J. Lee, G. Watson, A.A. Gupta, A.R. Abdul Razak. Analysis and/or interpretation of data: A. Salawu, E.R. Malone, E. Al-Ezzi, S. Genta, O. Vornicova, L. Wang, L. Arones, M. Phillips, J. Lee, G. Watson, A.A. Gupta, A.R. Abdul Razak. Approval of the version of the manuscript to be published: A. Salawu, E.R. Malone, E. Al-Ezzi, S. Genta, O. Vornicova, L. Wang, L. Arones, M. Phillips, J. Lee, G. Watson, A.A. Gupta, A.R. Abdul Razak.