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Article History

Accepted: 3 February 2025

First Online: 26 March 2025

Declarations

:

: This study was funded by Gilead Sciences, Inc.

: F.S., Y.L., K.S., D.J., Y.H., and M.H. are employees of Gilead Sciences, Inc. KS holds stock or stock options for Gilead Sciences, Inc. B.J. received research funding from Bristol Myers Squibb and Syntrix, grants from Gateway for Cancer Research outside the submitted work, and performed consulting services and served on speakers bureau for Taiho Oncology, Insmed Oncology, Gritstone Bio, and Incyte. N.J.L. received institutional research funding from ALX Therapeutics, Ascentage, Asana, Beigene, Constellation Pharma/MorphoSys, Alexion, Cerulean, Forty Seven, Alpine, Merck, Pfizer, InhibRx, Regeneron, Apexian, Formation Biologics (Forbius), Symphogen, CytomX, Sapience Therapeutics, Incyte, Jounce, Livzon, Northern Biologics, Innovent Biologics, Ikena, Odonate, Loxo, Alpine Biosciences, Mersana, Macrogenics, Helsinn, Seagen, Shattuck Labs, Samumed, Astellas, Alkermes, SK Life Sciences, KSQ Therapeutics, Tizona, Servier, Sapience, Repare Therapeutics, Gilead Sciences, Inc, Bristol Myers/Celgene, GSK, Janssen, Artios, Arcus Bio, and Volastra; and served on speakers bureaus for Innovent Biologics and Ikena. C.E. received institutional research funding from Jannsen, Pfizer, Sumitomo, and Merck; served on a speakers bureau for Mirati; and performed consulting for AbbVie, Amgen, Hoopika, IGMs, Merck, and Taiho. A.K. has nothing to declare.

: This trial was conducted in accordance with the US Food and Drug Administration and International Council for Harmonisation (ICH) Guidelines for Good Clinical Practice (GCP), the Declaration of Helsinki, and local authority requirements. Institutional review boards or independent ethics committees approved the study conduct at each study site. All patients provided written informed consent.

: Not applicable.

: Gilead Sciences shares anonymized individual patient data upon request or as required by law or regulation with qualified external researchers on the basis of submitted curriculum vitae and reflecting nonconflict of interest. The request proposal must also include a statistician. Approval of such requests is at Gilead Science’s discretion and is dependent on the nature of the request, the merit of the research proposed, the availability of the data, and the intended use of the data. Data requests should be sent to datarequest@gilead.com.

: Not applicable.

: G.A.F., M.P.C., F.S., Y.H., M.H., and C.E. carried out study conception and design; G.A.F., N.J.L., J.R.H., P.A.P., C.S., B.J., A.K., A.P., and C.E. carried out provision of study materials or patients; M.P.C., Y.L., K.S., D.J., and Y.H. carried out collection and assembly of data. All authors carried out data analysis and interpretation, manuscript writing, final approval of the manuscript, and are accountable for all aspects of the work.