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Article History

Accepted: 24 May 2025

First Online: 24 June 2025

Declarations

:

: This study was sponsored by Pfizer Inc.

: Gabrielle Rocque received research funding from Genentech, Pfizer Inc, and Daiichi Sankyo and consulting fees from Pfizer Inc, Gilead, and Armada. Joanne L. Blum reports acting as a paid consultant for Pfizer Inc and Tempus and on the speaker’s bureau of Pfizer Inc and Tempus. Yan Ji received compensation for being on advisory boards for Janssen, AstraZeneca, and BeiGene. Timothy Pluard reports acting as a paid consultant for Pfizer Inc, AstraZeneca, Jazz Pharmaceutical, Daiichi, and Gilead; receiving research funding (institution) from Daiichi Sankyo, Jazz Pharmaceuticals, Pfizer Inc, Sermonix, Scorpion, Merck, DualityBio, and Arvinas; participating in the speaker’s bureau of Gilead, AstraZeneca, and Stemline. John Migas reports contracted research (clinical trials) paid to his institution (Pfizer Inc, AstraZeneca, Jazz Pharmaceuticals). Shailendra Lakhanpal reports no conflicts of interest. Erin Jepsen reports being an employee of Novant Health Cancer Institute. Yao Wang, Zhe Zhang, and Eric Gauthier report being employees of and stockholders in Pfizer Inc. Monica Z. Montelongo reports being an employee of ICON and was funded by Pfizer Inc to conduct the study. Debu Tripathy reports contracted research (clinical trials) paid to his institution from Novartis, Pfizer Inc, and Polyphor and paid consultancy for AstraZeneca, OncoPep, GlaxoSmithKline, Gilead, Personalis, Sermonix, Pfizer Inc, Puma Biotechnology, Roche, Novartis, Menarini-Stemline, BeiGene, AMBRX, and Jazz Pharmaceuticals.

: Upon request, and subject to review, Pfizer will provide the data that support the findings of this study. Subject to certain criteria, conditions, and exceptions, Pfizer may also provide access to the related individual deidentified participant data. See for more information.

: The study was conducted in accordance with local regulatory and legal requirements and was reviewed and approved by applicable local institutional review boards or independent ethics committees. The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.

: All patients provided written informed consent before participating in the study.

: Not applicable.

: Not applicable.

: Conception/design: GBR, EG, and DT. Provision of study material or patients: GBR, JLB, TP, and DT. Collection and/or assembly of data: MZM. Data analysis and interpretation: GBR, JLB, MZM, ZZ, EG, and DT. Manuscript drafting and revision: all authors. Final approval of submitted manuscript: all authors.