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Article History

Accepted: 31 May 2025

First Online: 17 June 2025

Declarations

:

: Open access funding enabled and organized by Projekt DEAL. This study was funded by the DNPM (Deutsches Netzwerk für personalisierte Medizin) with the grant number: DNPM: 01NVF20006.

: Layla Tabea Riemann, Maximilian Ataian, Felicia P. S. Hähner, Benjamin Roth, Alexander Knurr, Anne Kamitz, Maximilian Christopeit, Carsten Bokemeyer, and Frank Ückert declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

: Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

: MONOCLE was approved by the ethics committee of the Hamburg Chambers of Physicians (approval number: 2023-101098-BO-ff).

: The code is available at Github .

: Conceptualization: Layla Tabea Riemann, Felicia P. S. Hähner, Maximilian Christopeit, Frank Ückert, and Carsten Bokemeyer. Methodology: Layla Tabea Riemann, Maximilian Ataian, Anne Kamitz, Alexander Knurr, Benjamin Roth, and Felicia P. S. Hähner. Formal analysis and investigation: Layla Tabea Riemann, Anne Kamitz, Alexander Knurr, and Maximilian Christopeit. Writing—original draft preparation: Layla Tabea Riemann. Writing—review and editing: Layla Tabea Riemann, Maximilian Christopeit, Anne Kamitz, Alexander Knurr, Felicia P. S. Hähner, Carsten Bokemeyer, and Frank Ückert. Funding acquisition: Maximilian Christopeit, Carsten Bokemeyer, and Frank Ückert. Resources: Carsten Bokemeyer and Frank Ückert. Supervision: Carsten Bokemeyer and Frank Ückert.

: Not applicable.

: Not applicable.