Document is current
Any future updates will be listed below
-
Authors
Jazieh, Khalid
Tsai, Jill
Solomon, Sheila
Zhu, Mojun
Pedersen, Katrina S.
Fernandez-Zapico, Martin E.
-
Funding
Funding for this research was provided by:
Norma Lee and Morton Funger Clinician Career Development Fund Award in Colon Cancer Research, Mayo Clinic
The Center for Clinical and Translational Science and the Center for Biomedical Discovery Pilot Awards for Team Science
Center for Clinical and Translational Science, Mayo Clinic (UL1 TR002377)
Mayo Clinic Department of Oncology FORIT Award
National Center for Advancing Translational Sciences (KL2 TR002379)
- License Information
-
More Information
Article History
Received: 17 September 2025
Accepted: 24 November 2025
First Online: 11 December 2025
Declarations
:
: JT and SS: Guardant Health (employees and stockholders); HX: Cardiff Oncology (institution), Dynamicure (institution), BioNTech SE (institution), Qurient Therapeutics (institution), SparX Biopharmaceutical Corp (institution), and Xilio Therapeutics (institution). Khalid Jazieh, Katrina S. Pedersen, and Martin E. Fernandez-Zapico declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.
: The first cohort (Guardant “national cohort”) was a deidentified dataset made available by Guardant Health (Palo Alto, CA, USA) for research purposes, with approval from the Advarra Institutional Review Board (Pro00034566). The second cohort consisted of patients with advanced or metastatic PDAC or CRC tested with Guardant360 assays at the Mayo Clinic from January 2016 to June 2023 (“Mayo cohort”), approved by the institutional review board (23-005258).
: Not applicable.
: Data, analytic methods, and study materials will or will not be made available to other researchers upon request to corresponding author Dr. Hao Xie.
: Not applicable.
: Khalid Jazieh: conception, design, data analysis, and manuscript preparation; Jill Tsai: conception, design, data analysis, and manuscript review; Sheila Solomon: data analysis and manuscript review; Mojun Zhu and Katrina S. Pedersen: manuscript review; Martin E. Fernandez-Zapico: design and manuscript review; Hao Xie: conception, design, and manuscript preparation and review.
