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Authors
Wakatsuki, Takeru https://orcid.org/0000-0002-1463-3859
Yamamoto, Noriko
Ishizuka, Naoki https://orcid.org/0000-0002-5856-9668
Hironaka, Shuichi https://orcid.org/0000-0001-9714-231X
Minashi, Keiko
Kadowaki, Shigenori https://orcid.org/0000-0001-9923-5309
Hirano, Hidekazu https://orcid.org/0000-0003-1343-1419
Shoji, Hirokazu https://orcid.org/0000-0002-8922-5227
Yamaguchi, Toshifumi https://orcid.org/0000-0003-1399-1918
Chin, Keisho https://orcid.org/0000-0002-2015-8185
Ogura, Mariko https://orcid.org/0000-0002-1004-8425
Nakayama, Izuma https://orcid.org/0000-0003-4987-1934
Osumi, Hiroki https://orcid.org/0000-0002-4742-0446
Ueki, Arisa https://orcid.org/0000-0001-9205-5452
Kitano, Shigehisa https://orcid.org/0000-0002-4041-8298
Boku, Narikazu https://orcid.org/0000-0002-1438-707X
Yamaguchi, Kensei https://orcid.org/0000-0001-6887-5709
Takahari, Daisuke https://orcid.org/0000-0002-2492-6014
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Funding
Funding for this research was provided by:
Cancer Institute Hospital of JFCR.
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Article History
Received: 17 November 2025
Accepted: 5 February 2026
First Online: 15 March 2026
Declarations
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: Shuichi Hironaka reports personal frees from Taiho and Chugai. Keiko Minashi reports grants from Taiho. Shigenori Kadowaki reports personal fees from Chugai and Taoho, as well as grants from Chugai. Hidekazu Hirano reports personal fees from Toiho and grants from Taiho. Izuma Nakayama reports personal fees from Taiho and Chugai, as well as grants from Chugai. Shigehisa Kitano reports personal fees from Taiho and Chugai, as well as grants from Chugai. Narikazu Boku reports personal fees from Taiho and Chugai. Kensei Yamaguchi reports personal fees from Taiho and Chugai, as well as grants from Taiho. Daisuke Takahari reports personal fees from Taiho, Chugai, and Yakult. Takeru Wakatsuki, Noriko Yamamoto, Naoki Ishizuka, Hirokazu Shoji, Toshifumi Yamaguchi, Keisho Chin, Mariko Ogura, Hiroki Osumi, and Arisa Ueki have no conflicts of interest that are directly relevant to the content of this article.
: The study was conducted in accordance with the Declaration of Helsinki and Ethical Guidelines for Clinical Studies in Japan. The study protocol was approved by the Ethics Committees of The Cancer Institute Hospital and those of each participating center before initiating enrollment (2015–27).
: All patients provided written informed consent for participation in the study.
: All patients provided written informed consent for publication of both the clinical trial and this collaborative study.
: The data generated in this study are not publicly available because of restrictions related to participant consent but is available upon reasonable request from the corresponding author.
: Not applicable.
: Conceptualization: TW; resources: TW, SH, KM, SK, HH, HS, KC, MO, IN, TY, DT, KY; data curation: TW; formal analysis: TW, NI; funding acquisition: KY; investigation: TW, NY; methodology: NB, NI, AU, SK, HH, HO; visualization: TW, NB; project administration: TW, DT; writing (original draft): TW; writing (review and editing: NB, AU, SH, KM, SK, HO, HH, SK, DT; supervision: KY.
