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The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function

Published Online: 2024-04-01

Published Print: 2024-08

Authors

Imamura, Michihiro https://orcid.org/0009-0000-8197-842X
Matsumoto, Hirokazu

Mannen, Hideyuki

Takeda, Shin’ichi

Aoki, Yoshitsugu
Funding

Funding for this research was provided by:

Japanese Society for the Promotion of Science (JP21500384, JP24500472, JP22K09870)

Intramural Research Grants for Neurological and Psychiatric Disorders of the National Center of Neurology and Psychiatry (2-5)

Collaborative Research Project of Brain Research Institute, Niigata University (21506, 22506)
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Text and Data Mining valid from 2024-04-01

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Article History

Received: 6 February 2024

Accepted: 18 March 2024

First Online: 1 April 2024

Declarations

:

: The authors declare no competing interests.

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