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Article History

Received: 2 March 2024

Accepted: 30 July 2024

First Online: 3 September 2024

Declarations

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: Toxoplasmosis is a serious opportunistic disease with limited treatment options. The current study’s goal was to assess the effectiveness of the ethanolic extract of <i>Z. officinale</i> in treating mice that had been infected with the RH <i>T. gondii</i> strain experimentally. Findings in the present study - as demonstrated by prolonged survival rate, reduced parasite burden, improved <i>T.gondii</i> associated liver injury and histopathological alterations - supported the strong therapeutic potential of ginger in the treatment of toxoplasmosis. We hypothesize that the antioxidant capacity of ginger is the underlying mechanism of its anti-<i>Toxoplasma</i> effect in the current study. Thus, our results suggested ginger can be considered a safe chemotherapeutic agent in the treatment of toxoplasmosis. Further studies are needed to determine the effective component in ginger which can be used as a pharmaceutical target in treatment of toxoplasmosis.

: This study was conducted after approval from the Ethics Committee of the Faculty of Medicine, Alexandria University, Egypt (<b>code: 0306090</b>). All animal experiments were conducted in accordance with the Declaration of Helsinki guidelines.

: The authors have no conflict of interest.