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Article History

Received: 13 October 2020

Accepted: 14 December 2020

First Online: 7 January 2021

Compliance with ethical standards

:

: Andrea Sonaglioni declares that he has no conflict of interest. Antonella Caminati reports personal fees from Roche and Boehringer Ingelheim, outside the submitted work. Roberto Lipsi declares that he has no conflict of interest. Michele Lombardo declares that he has no conflict of interest. Sergio Harari reports grants and personal fees from Roche, Actelion and Boehringer Ingelheim, outside the submitted work.

: All procedures performed in the present study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.